Sepsis-induced coagulopathy

Disseminated intravascular coagulation (DIC) is a life-threatening complication in sepsis and other critical conditions. Various diagnostic criteria for disseminated intravascular coagulation (DIC) have been established, but they are not commonly used in clinical practice. This includes the International Society on Thrombosis and Haemostasis (ISTH) overt-DIC score and the Japanese Society on Acute Medicine (JAAM) DIC score. The possible reasons would be the complexity, availability, and expense of the criteria. Under such conditions, sepsis-induced coagulopathy (SIC) scoring system was developed by the members of scientific and standardization committees (SSCs) of the ISTH and released in September 2017. Subsequently, in 2019, SIC was proposed as the criterion for an early and compensated phase of sepsis-associated DIC by the SSCs on DIC and Perioperative and Critical Care of the ISTH. All the DIC scoring systems utilize clinical laboratory results, platelet count, prothrombin time (PT), fibrinogen and for the ISTH and JAAM DIC scores fibrin/fibrinogen degradation products (D-dimer). A recent communication, published in January 2023, gives an update on this subject and continue to recommend SIC followed by overt DIC as a pragmatic diagnostic tool and a common platform for DIC research worldwide.
During this webinar, clinicians, clinical pathologists, PhDs, and clinical laboratory staff will have the opportunity to update their knowledge on the diagnosis of DIC with a special focus on the clinical laboratory contribution.